What Histological Techniques are Used to Study Genomic Stability?
Several histological techniques are employed to study genomic stability:
- Immunohistochemistry (IHC): This technique uses antibodies to detect specific proteins involved in DNA repair and cell cycle regulation. For instance, the presence of the protein p53 can indicate a cellular response to DNA damage. - Fluorescence In Situ Hybridization (FISH): FISH is used to detect chromosomal abnormalities and gene amplifications that are indicative of genomic instability. - Histopathological Staining: Various stains, such as Hematoxylin and Eosin (H&E), can reveal morphological changes in tissues that suggest genomic instability.
