Upon administration of the PCV, one can observe various histological changes in the lymphoid organs such as the spleen and lymph nodes. These changes include: - Germinal Center Formation: B cells proliferate and differentiate in the germinal centers of lymph nodes and spleen. - Plasma Cell Generation: These are terminally differentiated B cells that produce antibodies specific to the antigens present in the vaccine. - Memory Cell Formation: Some B and T cells become memory cells, which persist long-term and provide rapid immune responses upon subsequent exposures.
