What Histological Changes Occur in Motility Disorders?
Several motility disorders can affect the histological structure of the GI tract. For instance, in achalasia, the loss of inhibitory neurons in the esophagus leads to impaired relaxation of the lower esophageal sphincter. Histologically, this can be observed as a reduction in the number of neurons in the myenteric plexus. In Hirschsprung's disease, the absence of ganglion cells in the distal colon results in a lack of peristalsis and severe constipation.
