Gastrointestinal motility is regulated by a complex interplay of neural and hormonal signals. The enteric nervous system (ENS), often referred to as the "second brain," plays a critical role. This intricate network of neurons is embedded in the walls of the GI tract and can function independently of the central nervous system (CNS). Additionally, the autonomic nervous system (ANS) and various hormones, such as gastrin and motilin, influence motility.