What Histological Changes Occur in Lewy Body Dementia?
In addition to the presence of Lewy bodies, histological changes in LBD include neuronal loss, gliosis, and the formation of Lewy neurites. Neuronal loss is often observed in areas like the substantia nigra and cortex. Gliosis refers to the proliferation of glial cells in response to neuronal injury. Lewy neurites are abnormal, dystrophic neuronal processes that also contain alpha-synuclein.
