Histologically, Lewy bodies are identified using specific staining techniques. The most common method employs immunohistochemistry to detect the presence of alpha-synuclein. Lewy bodies appear as eosinophilic, round inclusions within the cytoplasm of neurons when stained with hematoxylin and eosin (H&E). Additional confirmation can be achieved with alpha-synuclein antibodies, which highlight these inclusions more specifically.
