What Histological Changes Occur During Re-epithelialization?
Histologically, the re-epithelialization process can be observed through several stages:
- Initial Response: The wound edges show a proliferation of basal keratinocytes. - Migration Phase: Keratinocytes at the wound edge flatten and migrate over the wound bed, forming a thin epithelial layer. - Proliferation Phase: The epithelial layer thickens as cells continue to proliferate. - Maturation Phase: The new epithelial layer undergoes differentiation, restoring the normal epidermal architecture.
