The process begins with the activation of keratinocytes at the wound edge. These cells undergo changes in shape and adhesion properties, allowing them to migrate over the wound bed. The following steps outline the re-epithelialization process:
1. Cell Migration: Keratinocytes detach from the basement membrane and move across the wound. 2. Cell Proliferation: To cover the wound area, keratinocytes proliferate extensively. 3. Cell Differentiation: Once the wound is covered, the cells differentiate to restore the normal stratified structure of the epidermis.
