Exposure to xenobiotics can lead to a variety of histological changes in tissues. These changes can include cellular hypertrophy, hyperplasia, necrosis, and fibrosis. For instance, chronic exposure to certain xenobiotics can cause liver tissues to develop fibrosis, which is characterized by the excessive accumulation of extracellular matrix components. Additionally, some xenobiotics can induce the formation of granulomas, which are organized collections of macrophages that form in response to chronic inflammation.
