What are the Limitations of Metabolic Studies in Histology?
Despite their utility, metabolic studies in histology have some limitations:
- Resolution and Sensitivity: Some techniques may not provide sufficient resolution or sensitivity to detect low-abundance metabolites.
- Complexity of Metabolism: Cellular metabolism is highly complex and dynamic. Isolating specific metabolic pathways and understanding their regulation can be challenging.
- Tissue Preparation: The process of fixing and preparing tissues for histological analysis can sometimes alter metabolic states, leading to artifacts.
