A compromised nutrient supply can lead to tissue damage and disease. Ischemia, a condition characterized by inadequate blood flow, can cause tissue hypoxia and necrosis. Chronic nutrient deprivation can trigger cellular adaptations, but prolonged deprivation often leads to irreversible damage. For example, in diabetes mellitus, impaired glucose uptake by cells can lead to energy deficits and complications like neuropathy and retinopathy.
