What Happens if Pro B Cell Development is Disrupted?
Disruptions in Pro B cell development can lead to severe immunodeficiencies or leukemias. For instance, mutations in genes involved in V(D)J recombination can result in a failure to produce functional B cells, leading to conditions such as Severe Combined Immunodeficiency (SCID). On the other hand, aberrant proliferation of Pro B cells can lead to B cell leukemias, highlighting the importance of tight regulatory mechanisms in B cell development.
