Several factors regulate megakaryopoiesis, including:
Thrombopoietin (TPO): TPO is the primary cytokine that regulates megakaryocyte production and differentiation. It binds to the c-Mpl receptor on megakaryocytes and their precursors, promoting their proliferation and maturation. Interleukins: Various interleukins, such as IL-3, IL-6, and IL-11, also play a role in enhancing megakaryocyte development. Stem Cell Factor (SCF): SCF synergizes with TPO to support the proliferation and differentiation of hematopoietic progenitor cells into megakaryocytes.
