The ovarian tissue in PCOS presents several changes when analyzed histologically: 1. Cyst Formation: The small cysts are usually located peripherally and measure 2-9 mm in diameter. 2. Thickened Tunica Albuginea: The outer covering of the ovary, known as the tunica albuginea, is often thickened. 3. Hyperplasia of Theca Cells: There is an increase in the number of theca cells, which are responsible for androgen production. 4. Increased Stromal Matrix: The stroma, or connective tissue, of the ovary is often denser and contains more collagen.
