Connective tissues such as ligaments and tendons are also affected by immobilization. Histological examination shows a disorganization of collagen fibers and a decrease in the synthesis of new collagen. This leads to a reduction in the tensile strength and elasticity of these tissues. Additionally, there is often an increase in the activity of matrix metalloproteinases (MMPs), enzymes that degrade extracellular matrix components, further weakening the structural integrity of the connective tissues.
