Axonal degeneration can be induced by several factors:
Physical injury: Trauma to the nervous system can sever axons, leading to degeneration. Neurodegenerative diseases: Conditions like Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis (ALS) often involve axonal degeneration. Genetic mutations: Certain genetic disorders can impair the structural integrity of axons or interfere with their metabolic processes. Toxins: Exposure to neurotoxins can disrupt axonal integrity and function.