What are the Therapeutic Implications of Targeting KMTs?
Given their central role in gene regulation and disease, KMTs present promising therapeutic targets, particularly in cancer. Small molecule inhibitors of KMTs are currently under development and clinical trials. For instance, inhibitors targeting EZH2 have shown potential in treating certain types of lymphomas and solid tumors. By modulating the activity of KMTs, it is possible to restore normal gene expression patterns and counteract the effects of aberrant methylation.
