What are the pathological implications of NHE1 dysfunction?
Abnormal NHE1 activity is associated with various diseases:
Cardiovascular Diseases: Overactivation of NHE1 can contribute to conditions like cardiac hypertrophy and heart failure. Cancer: NHE1 is often upregulated in cancer cells, promoting an alkaline intracellular environment that supports uncontrolled cell proliferation. Neurological Disorders: Dysregulation of NHE1 is linked to neurodegenerative diseases and damage following ischemic events.