What are the Pathological Implications of Katanin Dysfunction?
Dysfunction of katanin can have significant pathological consequences:
- Neurodegenerative Diseases: Abnormal katanin activity has been linked to diseases such as Alzheimer's and Parkinson's, where improper microtubule dynamics can lead to neuronal damage. - Cancer: Altered katanin activity can affect cell division and migration, contributing to cancer progression and metastasis. - Developmental Disorders: Mutations in katanin subunits can lead to developmental defects due to improper neuronal development and cell division.
