What are the Pathological Implications of Cholinergic Neuron Dysfunction?
Dysfunction of cholinergic neurons is implicated in various neurological disorders. For instance, a significant loss of cholinergic neurons in the basal forebrain is a hallmark of Alzheimer's disease, contributing to cognitive decline. In Parkinson's disease, cholinergic dysfunction in the brainstem is associated with motor and non-motor symptoms. Moreover, cholinergic deficits are also observed in myasthenia gravis, an autoimmune disorder affecting neuromuscular transmission.
