Several factors influence TEWL, which can be studied through histological techniques:
1. Stratum Corneum Thickness: A thicker stratum corneum generally provides a better barrier to water loss. 2. Lipid Content: The intercellular lipids in the stratum corneum play a pivotal role in maintaining hydration. 3. Cell Cohesion: Properly functioning desmosomes and other cell junctions ensure the cohesion of the stratum corneum, reducing water loss. 4. Cornification: The process of keratinocyte differentiation and eventual formation of the stratum corneum is crucial for barrier function.
