What are the Pathological Implications of Altered Gli Activity?
Altered Gli activity is commonly associated with various pathological conditions. For instance, overactivation of Gli1 and Gli2 can lead to uncontrolled cell proliferation and tumorigenesis. Conversely, loss of Gli3 function can result in developmental disorders such as Greig cephalopolysyndactyly syndrome. In cancer, Gli transcription factors often contribute to the maintenance of cancer stem cells, making them a target for therapeutic interventions.