While Melan A is a highly specific marker, it does have certain limitations:
False Positives: Occasionally, other cell types may exhibit Melan A expression, leading to false-positive results. False Negatives: Some melanoma variants may not express Melan A, resulting in false-negative findings. Technical Variability: The accuracy of IHC can be influenced by factors such as antibody quality, tissue preservation, and staining protocols.
