The primary cellular components involved in inflammation include neutrophils, macrophages, lymphocytes, and mast cells. Neutrophils are usually the first to arrive at the site of inflammation and are essential for phagocytosing bacteria and other pathogens. Macrophages follow and are crucial for both phagocytosis and the regulation of the inflammatory response. Lymphocytes are involved in chronic inflammation and adaptive immunity, while mast cells release histamine and other mediators that contribute to the inflammatory response.