What are the Histological Features of Lipid Storage Diseases?
In histology, lipid storage diseases often present with characteristic cellular changes. For instance, cells may appear swollen due to the accumulation of lipid-laden lysosomes. In Gaucher disease, for example, macrophages, termed Gaucher cells, exhibit a crumpled tissue paper appearance due to the accumulation of glucocerebroside. In Tay-Sachs disease, neurons show a ballooned appearance with prominent cytoplasmic vacuoles filled with gangliosides.
