What are the Implications of Double Strand Breaks in Disease?
Deficiencies in DSB repair mechanisms are linked to various diseases. For instance, mutations in genes involved in HR, such as BRCA1 and BRCA2, are associated with a higher risk of breast and ovarian cancer. Understanding DSBs and their repair mechanisms helps in developing targeted therapies, such as PARP inhibitors, which exploit the DNA repair weaknesses in cancer cells.
