What are the Implications of 3β-HSD Dysregulation?
Dysregulation of 3β-HSD can lead to various clinical conditions. For instance, mutations in the genes encoding 3β-HSD can result in congenital adrenal hyperplasia (CAH), a disorder characterized by impaired production of cortisol and aldosterone. Additionally, altered 3β-HSD activity has been implicated in certain cancers, such as prostate cancer and breast cancer, where local steroidogenesis may promote tumor growth.