What are the Histological Indicators of Metabolic Imbalances?
Histological indicators of metabolic imbalances include:
Cellular Swelling: Often due to the accumulation of water as a result of electrolyte imbalances. Lipid Accumulation: Seen as vacuoles within cells, common in liver tissue affected by fatty liver disease. Glycogen Accumulation: Appears as clear vacuoles in periodic acid-Schiff (PAS) staining, characteristic of glycogen storage diseases. Amyloid Deposits: Extracellular protein deposits that can disrupt normal tissue architecture, often seen in conditions like amyloidosis. Pigment Accumulation: Such as hemosiderin in cases of iron overload or melanin in pigmented tumors.
