What are the Histological Features of Ischemic Tissue?
Histologically, ischemic tissue exhibits several characteristic changes. Initially, cells may show swelling due to the influx of water. As ischemia progresses, cells exhibit pyknosis, or condensation of the nucleus, followed by karyorrhexis (fragmentation of the nucleus) and karyolysis (dissolution of the nucleus). Cytoplasmic changes include increased eosinophilia, reflecting protein denaturation, and the loss of cellular detail due to enzyme-mediated digestion.
