What are the Histological Features of IL-17 Activity?
In histological studies, IL-17 activity can be observed through the increased presence of immune cells such as neutrophils and macrophages in tissue samples. This infiltration is often accompanied by tissue remodeling and fibrosis in chronic inflammatory conditions. The cytokine also induces the expression of various matrix metalloproteinases (MMPs), which are involved in the breakdown of extracellular matrix components, contributing to tissue remodeling.
