Histological examination reveals various characteristic features depending on the type of GI cancer:
- Esophageal Cancer: Squamous cell carcinoma shows keratinization and intercellular bridges, while adenocarcinoma presents with glandular structures. - Gastric Cancer: Histology shows irregular gland formation, signet ring cells, and mucin production in diffuse type. - Colorectal Cancer: Identified by glandular structures with varying degrees of differentiation, and sometimes mucinous components. - Pancreatic Cancer: Displays dense desmoplastic stroma, irregular glandular patterns, and perineural invasion. - Liver Cancer: Exhibits trabecular, pseudoglandular, or solid patterns, often with bile production by tumor cells.