What are the Histological Features of Carcinogenesis?
Histologically, carcinogenesis is marked by several key features:
Atypia: Cells show abnormal morphology, including changes in size, shape, and nuclear features. Increased Mitotic Activity: An increased number of cells are found in mitosis, indicating rapid cell division. Loss of Differentiation: Cells lose their specialized functions and resemble undifferentiated or stem cells. Invasion: Tumor cells penetrate the basement membrane and invade surrounding tissues. Angiogenesis: Formation of new blood vessels to supply the growing tumor with nutrients and oxygen.
