What are the Histological Features of Amyotrophic Lateral Sclerosis (ALS)?
ALS is marked by the degeneration of motor neurons in the spinal cord, brainstem, and cortex. Histological examination reveals loss of motor neurons, gliosis, and the presence of Bunina bodies, which are cytoplasmic inclusions in surviving motor neurons. Ubiquitin-positive inclusions can also be seen.
