In histological studies, bradykinin has been observed to induce several key changes:
Vasodilation: Bradykinin causes the relaxation of smooth muscle cells in blood vessels, leading to vasodilation. This increases blood flow and can be observed as enlarged blood vessels in tissue sections. Increased Vascular Permeability: It enhances the permeability of blood vessels, allowing proteins and cells to exit the bloodstream and enter tissues. This can be visualized as edema or swelling in the affected tissues. Inflammation: Bradykinin is a potent mediator of inflammation, attracting leukocytes to the site of injury. In histological slides, an influx of inflammatory cells such as neutrophils and macrophages can be observed. Pain Induction: By acting on sensory neurons, bradykinin contributes to the sensation of pain. This aspect is more functional but has histological correlates in terms of nerve fiber changes.
