What are the histological changes seen in chronic pancreatitis?
Chronic pancreatitis is characterized by persistent inflammation, fibrosis, and loss of acinar cell mass. The histology reveals dense fibrotic tissue replacing the normal pancreatic parenchyma, along with atrophy of the acinar cells. The islets of Langerhans may remain relatively preserved initially but can be affected as the disease progresses, leading to endocrine dysfunction.
