How does acute pancreatitis affect the histology of the pancreas?
In acute pancreatitis, the histological features are marked by extensive inflammation, edema, and necrosis. The acinar cells undergo autodigestion due to premature enzyme activation. This leads to the formation of areas of fat necrosis and hemorrhage. In severe cases, the damage can extend to the surrounding tissues, including blood vessels, leading to hemorrhagic pancreatitis.
