What are the Consequences of Disorganized Microfibrils?
The disorganization of microfibrils can lead to a variety of clinical manifestations. In the case of Marfan syndrome, it can result in cardiovascular complications, such as aortic aneurysms and dissections. In Ehlers-Danlos syndrome, it can lead to hyperelastic skin, joint hypermobility, and increased susceptibility to bruising and bleeding. Disorganized microfibrils can also compromise wound healing and tissue regeneration.
