The major components of the organic matrix include:
Collagen: The most abundant protein, providing tensile strength and flexibility. Proteoglycans: These large molecules consist of a protein core attached to glycosaminoglycan (GAG) chains, contributing to the matrix's viscosity and ability to resist compressive forces. Glycoproteins: These proteins, which have carbohydrate groups attached, play roles in cell adhesion, signaling, and the stabilization of the matrix structure. Non-collagenous proteins: These include osteocalcin, osteopontin, and bone sialoprotein, which are involved in the regulation of mineralization and matrix organization.