The Notch signaling pathway involves several components:
Notch Receptors: There are four Notch receptors in mammals (Notch1-4). Ligands: The primary ligands are Delta-like (Dll1, Dll3, Dll4) and Jagged (Jag1, Jag2). Proteolytic Enzymes: ADAM proteases and γ-secretase complex are responsible for receptor cleavage. Transcriptional Regulators: RBP-Jκ/CSL, Mastermind-like (MAML) proteins, and other co-activators and co-repressors.
