What are Some Therapeutic Implications of Notch Signaling?
Given its role in various diseases, Notch signaling is a target for therapeutic intervention. γ-Secretase inhibitors (GSIs) are being explored in clinical trials to inhibit Notch signaling in cancers. Additionally, monoclonal antibodies targeting Notch receptors or ligands are being developed to modulate the pathway in diseases like cancer and Alzheimer's disease.