What are the Common Types of Lysosomal Storage Diseases?
There are over 50 different LSDs, but some of the most well-known include:
1. Gaucher Disease: Caused by a deficiency in the enzyme glucocerebrosidase, leading to the accumulation of glucocerebroside. 2. Tay-Sachs Disease: Caused by a deficiency in hexosaminidase A, resulting in the accumulation of GM2 ganglioside. 3. Fabry Disease: Caused by a deficiency in alpha-galactosidase A, leading to the accumulation of globotriaosylceramide. 4. Pompe Disease: Caused by a deficiency in acid alpha-glucosidase, resulting in the accumulation of glycogen. 5. Hurler Syndrome: Caused by a deficiency in alpha-L-iduronidase, leading to the accumulation of glycosaminoglycans.
