What are the Common Challenges in Allogeneic Transplants?
1. Rejection: Despite careful matching, allogeneic transplants can be rejected by the recipient's immune system. Histologically, this is seen as lymphocytic infiltration, tissue necrosis, and fibrosis.
2. Infections: Immunosuppressed patients are more susceptible to infections, which can complicate the transplant. Histology can help identify infectious agents and the extent of tissue damage.
3. Chronic Rejection: Unlike acute rejection, chronic rejection happens over months to years and is characterized by progressive fibrosis and vascular changes. Histological monitoring is essential for early detection and management.
