What are the Clinical Implications of Rho GTPases?
Abnormal Rho GTPase activity has been linked to various diseases. For example, overactivation of RhoA has been associated with cancer cell metastasis. Understanding the role of Rho GTPases in cell migration and invasion is critical for developing targeted therapies. Additionally, mutations in Rho GTPases or their regulators can lead to neurodegenerative diseases, emphasizing the need for further research in this area.
