What are the Clinical Implications of Cofilin Dysregulation?
Dysregulation of cofilin activity has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. For instance, in cancer, aberrant cofilin activity can lead to increased cell migration and invasion, contributing to metastasis. In neurodegenerative diseases, altered cofilin phosphorylation states have been associated with synaptic dysfunction and neuronal death.
