What are the Clinical Implications of Abnormal O-Linked Glycosylation?
Abnormal O-linked glycosylation has been linked to a variety of diseases. For instance, altered glycosylation patterns are often observed in cancer cells and can affect tumor progression and metastasis. In addition, congenital disorders of glycosylation are a group of rare genetic conditions caused by defects in glycosylation enzymes, leading to severe developmental and metabolic issues.
