Despite the advancements, several challenges remain:
1. Variability in Sample Quality: Differences in tissue handling and processing can affect the quality of the samples, leading to inconsistent results. 2. Technical Limitations: While technology has advanced, there are still limitations in terms of resolution, sensitivity, and specificity of certain techniques. 3. Human Factors: Errors can occur due to fatigue, lack of training, or oversight by technicians. 4. Resource Constraints: Limited access to advanced technology and training resources can hinder the implementation of best practices in some laboratories.