What are the Challenges in Studying Proto Oncogenes?
Studying proto oncogenes in histology presents several challenges: - Heterogeneity of Tumors: Tumors often exhibit significant cellular diversity, making it difficult to identify and analyze proto oncogene alterations uniformly. - Sensitivity of Detection Methods: Ensuring that detection methods like IHC and ISH are sensitive and specific enough to accurately measure proto oncogene expression. - Interpretation of Data: Differentiating between normal and pathological expression levels of proto oncogenes requires expertise and careful analysis.