proto oncogenes

What are the Challenges in Studying Proto Oncogenes?

Studying proto oncogenes in histology presents several challenges:
- Heterogeneity of Tumors: Tumors often exhibit significant cellular diversity, making it difficult to identify and analyze proto oncogene alterations uniformly.
- Sensitivity of Detection Methods: Ensuring that detection methods like IHC and ISH are sensitive and specific enough to accurately measure proto oncogene expression.
- Interpretation of Data: Differentiating between normal and pathological expression levels of proto oncogenes requires expertise and careful analysis.

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