In histology, proto oncogenes can be studied using various techniques. Immunohistochemistry (IHC) is widely used to detect the expression of proto oncogene proteins within tissue samples. By using specific antibodies that bind to these proteins, researchers can visualize their localization and abundance in different cell types. Additionally, in situ hybridization (ISH) techniques can be employed to detect mRNA transcripts of proto oncogenes, providing insights into their gene expression patterns.