What are the Challenges in Studying Lipid Raft Mediated Endocytosis?

Studying lipid raft mediated endocytosis poses several challenges. One major challenge is the difficulty in isolating and studying lipid rafts due to their dynamic and small size. Additionally, the functional heterogeneity of lipid rafts complicates the understanding of their specific roles in different cellular contexts. Advanced imaging techniques and biochemical methods are continuously being developed to overcome these challenges.