What Are the Challenges in Histological Analysis of CAR T Cell Therapy?
Despite its importance, histological analysis of CAR T cell therapy faces several challenges:
- Heterogeneity of Tumors: Tumors are often heterogeneous, making it difficult to identify uniform target antigens. - Dynamic Changes: The rapid and dynamic changes post-therapy require timely and repeated sampling. - Technical Limitations: Advanced techniques like multiplex IHC are needed to visualize multiple markers simultaneously, which can be technically challenging.
